The worst stock I ever bought was GVBP, but I was lucky and got out of it just as the **** was hitting the fan (It was a classic pump and dump, got halted by the SEC, all that bad stuff).
The most money I've lost thus far was from CXM. I was an idiot and held on to half my shares after it released it's phase II results which were supposedly positive. It dropped from around $2 to $0.50 in the following two months (dilution didn't help matters either).



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